Vol 1, Issue 1 | May 2026

This study was carried out to evaluate the effect of addiction and functional impotence on male fertility. Semen analysis of 125 males was performed. Five groups of 25 subjects each were studied: fertile controls, tobacco chewers, smokers, alcoholics, and functional impotents. Physical parameters assessed included volume, motility, and sperm count; biochemical parameters included ascorbic acid and fructose concentrations. Total sperm count and total motile sperm count were significantly decreased in tobacco chewers, smokers, and alcoholics. In the functional impotents group, total sperm count showed a non-significant decrease, while the decrease in total motile sperm count was significant. Ascorbic acid concentration was lower across all study groups compared to controls, though not statistically significant. Fructose concentration was significantly higher in all study groups compared to controls, indicating an inverse relationship with sperm density. The study concludes that addictions and functional impotence reduce male fertility potential.

Background: Ocular dominance is the tendency to prefer visual input from one eye over the other. Visual Evoked Potentials (VEPs) are electrical potentials recorded from the scalp in response to visual stimuli, assessing conduction from the retina to the occipital cortex. Objectives: (1) To determine ocular dominance in normal healthy subjects; (2) To compare latency and amplitude of VEP components in dominant and non-dominant eyes. Materials and Methods: Ocular dominance was determined in 100 normal healthy subjects using Miles and Porta tests, followed by VEP recording. Results: Right eye dominance was found in 75% and left eye dominance in 25% of subjects. Amplitude was significantly higher in the dominant eye (P<0.001). Latency of N70 and P100 was significantly shorter in the dominant eye (P=0.006 and P<0.001, respectively). N155 showed no significant difference. Conclusion: These findings provide electrophysiological evidence of lateralization in the central nervous system.

Coronary Artery Disease (CAD) is a leading cause of global morbidity and mortality, with both environmental and genetic factors implicated. The Renin-Angiotensin System (RAS) plays an important role in the pathogenesis of CAD. This study examined the association of ACE I/D, AGT M235T, and AT1R A1166C gene polymorphisms with the severity of CAD in 150 angiographically confirmed CAD patients and 150 healthy controls from north coastal Andhra Pradesh, India. Severity was classified as Single Vessel Disease (SVD), Double Vessel Disease (DVD), and Triple Vessel Disease (TVD). The ACE DD genotype (OR 4.5, P=0.03) and AGT TT genotype (OR 12.61, P=0.0003) were significantly more frequent in CAD cases than controls. TVD was most frequently associated with the ACE DD genotype (P<0.001) and AGT TT genotype (P=0.016). AT1R gene polymorphism showed no significant association with severity. These findings suggest that ACE and AGT risk genotypes may predict disease prognosis and assist in clinical management of CAD.

Objectives: To evaluate the antimicrobial efficacy of herbal and chlorhexidine mouth rinses against Streptococcus mutans. Search Strategy: Electronic databases including Cochrane Central Register of Controlled Trials, PubMed, LILACS/BBO, MEDLINE, and ScienceDirect were searched until June 2012. Selection Criteria: In-vitro studies comparing herbal and chlorhexidine mouth rinse using zone of inhibition and minimum inhibitory concentration (MIC) as outcome measures were included. Results: Six in-vitro studies were included. Meta-analysis using the random effects model showed a pooled standardized mean difference of 0.891 in favour of chlorhexidine. Conclusion: Chlorhexidine mouth rinse demonstrated better antimicrobial efficacy against Streptococcus mutans compared to herbal mouth rinses. Further in-vivo clinical trials are essential to validate the in-vitro findings.

The establishment of anterior guidance represents a fundamental yet demanding component of comprehensive restorative treatment planning. When carefully designed, it is pivotal in achieving harmonious function, pleasing aesthetics, patient comfort, and optimal phonetics. This article describes the rehabilitation of a patient who presented with missing anterior teeth and generalized dental attrition following periodontal compromise. The anterior guidance developed during the provisional phase was meticulously preserved through the use of a customized incisal guide table fabricated in autopolymerizing acrylic resin. Intraoral scanning and digital smile design were employed to enhance precision. This structured approach allowed for the precise transfer of established functional parameters to the definitive restorations, ensuring accuracy, consistency, and a predictable clinical outcome. The patient demonstrated high satisfaction with aesthetics and maintained excellent oral hygiene compliance throughout follow-up.